Immunomodulatory effect of hypertonic saline in hemorrhagic shock
نویسندگان
چکیده
منابع مشابه
The Use of Hypertonic Saline in Management of Hemorrhagic Shock
Background: The most appropriate solution for volume replacement in hemorrhagic shock is controversial, however, hypertonic saline (HTS) solutions have recently gained widespread acceptance. Aim of the work: to study the use of hypertonic saline with the resuscitation fluids in patients with hemorrhagic shock to evaluate the impact of this solution on the extent of early bacterial translocation...
متن کاملHypertonic Saline Dextran Ameliorates Organ Damage in Beagle Hemorrhagic Shock
OBJECTIVE The goal of this study was to investigate the effect of hypertonic saline with 6% Dextran-70 (HSD) resuscitation on organ damage and the resuscitation efficiency of the combination of HSD and lactated ringers (LR) in a model of hemorrhage shock in dogs. METHODS Beagles were bled to hold their mean arterial pressure (MAP) at 50 ± 5 mmHg for 1 h. After hemorrhage, beagles were divided...
متن کاملEffect of ATP-MgCl2-hypertonic solution (NaCl5%) administration on hemorrhagic shock
Introduction: In the recent years, effect of hypertonic solution in resuscitation of shock has been shown by clinical and laboratory studies. On the other hand ATP-MgCl2 is used for better tissue perfusion and cardiac output in shock. The aim of this study is evaluation of ATP-MgCl2 with hypertonic solution in resuscitation of hemorrhagic shock. Materials and Methods: In this experimental stud...
متن کاملHypertonic saline solutions in shock resuscitation.
Hypertonic saline solutions (HSS) have several characteristics that may improve the survival of patients during the initial treatment of certain types of shock. The use of isotonic crystalloids for resuscitation has several limitations: large infusion volumes are needed to increase the intravascular space; these large volumes cannot be given rapidly; and the fluid rapidly redistributes througho...
متن کاملImmunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock.
Hypertonic resuscitation fluids are known to be effective in restoring circulating volume in the hypovolemic trauma patient. Previous studies have suggested that hypertonicity might exert effects on immune cells leading to an altered host response. The present studies evaluated the effect of hypertonic resuscitation on the development of lung injury in a hemorrhagic shock model in which anteced...
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ژورنال
عنوان ژورنال: DARU Journal of Pharmaceutical Sciences
سال: 2015
ISSN: 2008-2231
DOI: 10.1186/s40199-015-0130-9